牛津柯维德疫苗在老年人中的应用“令人鼓舞”

2020-11-19 15:35

Covid: Oxford vaccine shows 'encouraging' immune response in older adults IoH世界播

Covid:牛津疫苗显示老年人的免疫反应令人振奋。IoH世界播


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Elisa Granato was one of the volunteers given the Oxford vaccine IoH世界播

伊莉莎·格拉纳托是接受牛津疫苗的志愿者之一IoH世界播


The Oxford coronavirus vaccine shows a strong immune response in adults in their 60s and 70s, raising hopes that it can protect age groups most at risk from the virus. IoH世界播

牛津冠状病毒疫苗在60多岁和70多岁的成年人中表现出强烈的免疫反应,这让人们燃起了希望,认为它可以保护最有可能感染病毒的年龄段。IoH世界播


Researchers say the Lancet phase two findings, based on 560 healthy adult volunteers, are "encouraging". IoH世界播

研究人员称,基于560名健康成年志愿者的《柳叶刀》第二阶段研究结果令人“振奋”。IoH世界播


They are also testing whether the vaccine stops people developing Covid-19 in larger, phase three trials. IoH世界播

他们还在测试疫苗是否能阻止人们在更大规模的第三阶段试验中发展成新冠肺炎。IoH世界播


Early results from this crucial stage are expected in the coming weeks. IoH世界播

这一关键阶段的初步结果预计将在未来几周内公布。IoH世界播


Three vaccines - Pfizer-BioNTech, Sputnik and Moderna - have already reported good preliminary data from phase three trials, with one suggesting 94% of over-65s could be protected from Covid-19. IoH世界播

辉瑞生物科技(Pfizer-BioNTech)、人造卫星(Sputnik)和摩德纳(Modina)这三种疫苗已经在第三阶段试验中报告了良好的初步数据,其中一种疫苗表明,65岁以上的人中有94%可以免受新冠肺炎的伤害。IoH世界播


The UK has already ordered 100 million doses of the Oxford vaccine, manufactured by AstraZeneca, 40 million doses of the Pfizer-BioNTech vaccine and five million of the Moderna vaccine. IoH世界播

英国已经订购了1亿剂阿斯利康(AstraZeneca)生产的牛津疫苗、4000万剂辉瑞生物科技(Pfizer-BioNTech)疫苗和500万剂现代疫苗。IoH世界播


The challenge with developing a Covid vaccine is to trigger the body to fight back against the virus no matter how old someone is. IoH世界播

开发Covid疫苗的挑战是,无论一个人多大年纪,都要触发身体对病毒进行反击。IoH世界播


Older people's weaker immune systems mean vaccines do not tend to function as well as they do in younger people. IoH世界播

老年人的免疫系统较弱,这意味着疫苗往往不会像年轻人那样发挥作用。IoH世界播


These trial results from the University of Oxford, peer-reviewed in the Lancet, suggest that may not be a problem. IoH世界播

牛津大学在《柳叶刀》杂志上发表的同行评议的这些试验结果表明,这可能不是问题。IoH世界播


They show that older adults aged 56-69 and over 70 had a similar immune response to younger adults aged 18-55. IoH世界播

研究表明,56-69岁和70岁以上的老年人对18-55岁的年轻人有类似的免疫反应。IoH世界播


'Protect most vulnerable' IoH世界播

“保护最脆弱的人”IoH世界播


Dr Maheshi Ramasamy, an investigator at the Oxford Vaccine Group, said: "We were pleased to see that our vaccine was not only well tolerated in older adults, but also stimulated similar immune responses to those seen in younger volunteers. IoH世界播

牛津疫苗集团的研究员马赫希·拉马萨米博士说:“我们很高兴看到我们的疫苗不仅在老年人中有很好的耐受性,而且还激发了与年轻志愿者相似的免疫反应。”IoH世界播


"The next step will be to see if this translates into protection from the disease itself." IoH世界播

“下一步将是观察这是否会转化为对疾病本身的保护。”IoH世界播


Two weeks after the second dose, more than 99% of participants had neutralising antibody responses. These included people of all ages. IoH世界播

第二次接种两周后,超过99%的参与者出现了中和抗体反应。这些人包括各个年龄段的人。IoH世界播


The T-cell response - another measure of how well the immune system responds - peaked two weeks after the first dose of the vaccine, regardless of age. IoH世界播

T细胞反应--另一个衡量免疫系统反应好坏的指标--在第一针疫苗接种两周后达到峰值,无论年龄大小。IoH世界播


"The robust antibody and T-cell responses seen in older people in our study are encouraging," Dr Ramasamy said. IoH世界播

拉马萨米博士说:“在我们的研究中,在老年人身上发现的强大抗体和T细胞反应令人鼓舞。”IoH世界播


"The populations at greatest risk of serious Covid-19 disease include people with existing health conditions and older adults. IoH世界播

“新冠肺炎严重患病风险最高的人群包括既有健康状况的人和老年人。IoH世界播


"We hope that this means our vaccine will help to protect some of the most vulnerable people in society, but further research will be needed before we can be sure." IoH世界播

“我们希望这意味着我们的疫苗将有助于保护社会上一些最脆弱的人群,但在我们确定之前,还需要进一步的研究。”IoH世界播


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Older adults were also less likely to experience side-effects, which were usually mild. IoH世界播

老年人也不太可能经历通常轻微的副作用。IoH世界播


And there were no serious safety issues relating to the vaccine, called ChAdOx1 nCov-2019. IoH世界播

而且,这种名为ChAdOx1 NCoV-2019的疫苗没有严重的安全问题。IoH世界播


Volunteers in the trial were put into groups and given one or two doses of the vaccine or a dummy jab. The reaction of their immune systems was assessed on the day they got the jab, then one, two and four weeks after both doses. IoH世界播

试验中的志愿者被分成几组,分别接种一到两剂疫苗或模拟注射。在他们注射疫苗的当天,然后在两次注射后的一周、两周和四周,对他们的免疫系统的反应进行了评估。IoH世界播


The Oxford vaccine is made from a weakened version of a common cold virus (known as an adenovirus) from chimpanzees that has been modified so it cannot grow in humans. IoH世界播

牛津疫苗是由一种来自黑猩猩的普通感冒病毒(称为腺病毒)的弱化版本制成的,这种病毒经过改造后不能在人类体内生长。IoH世界播


Work began on the vaccine in January and it was developed in under three months, starting human trials - the first in Europe - in April in Oxford. IoH世界播

疫苗的研究工作从1月份开始,在不到3个月的时间里就开发出来了,4月份在牛津开始了人体试验--这是欧洲第一次。IoH世界播


Phase three trials of the vaccine, which look at how efficient it is at protecting people against the Covid-19, started at the end of August and are still continuing. IoH世界播

疫苗的第三阶段试验于8月底开始,目前仍在继续。该阶段的试验旨在观察疫苗在保护人们免受新冠肺炎感染方面的有效性。IoH世界播


When data from this stage is sent to the regulators, scrutinised and approved, the vaccine can be given the green light to be used on people worldwide. IoH世界播

当这一阶段的数据被发送给监管机构并经过审查和批准后,疫苗就可以获准在世界各地的人们身上使用。IoH世界播


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*BRAND NEW PODCAST: How to Vaccinate the World - who will get priority? IoH世界播

*全新播客:如何为世界接种疫苗--谁将优先?IoH世界播


*RADIO 1'S POWER DOWN PLAYLIST: Billie Eilish gives us two hours of blissed-out warm sounds to relax to IoH世界播

*Radio 1的关机播放列表:Billie Eilish给我们提供了两个小时令人愉悦的温暖声音,让我们放松下来IoH世界播


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